Sirius is the brightest star as seen from Earth and is visible from both hemispheres. It lies just 8.6 light-years away, in the constellation Canis Major.
The galactic anticenter is opposite the Milky Way's center from our viewpoint on Earth. The closest bright star to the anticenter is Taurus the Bull's Elnath.
Blue-white Rigel shines as the brightest star in the constellation Orion the Hunter. It's a hot massive star, that someday will explode as a supernova.
The 6th-brightest star in the night sky, Capella, in the Northern Hemisphere constellation Auriga the Charioteer, is also a point of the Winter Hexagon.