Long considered to be little more than putty in the brain and spinal cord, the star-shaped astrocyte – the most common cell in the human nervous system – has found new respect among neuroscientists. They have begun to recognize its many functions in the brain, not to mention its role in a range of disorders of the central nervous system. A research group led by University of Wisconsin-Madison stem cell researcher Su-Chun Zhang reports it has been able to direct embryonic and induced human stem cells to become astrocytes in a lab dish. The results of their research appear in the May 22, 2011 issue of the journal Nature Biotechnology.
The ability to make large, uniform batches of astrocytes, explains Zhang, opens a new avenue to more fully understanding the functional roles of the brain’s most commonplace cell, as well as its involvement in a host of central nervous system disorders ranging from headaches to dementia. What’s more, the ability to culture the cells gives researchers a powerful tool to devise new therapies and drugs for neurological disorders.
Zhang, a researcher at UW-Madison’s Waisman Center and a professor of neuroscience in the UW School of Medicine and Public Health, said:
Not a lot of attention has been paid to these cells because human astrocytes have been hard to get. But we can make billions or trillions of them from a single stem cell.
Although astrocytes have gotten short shrift from science compared to neurons, the large filamentous cells that process and transmit information, scientists are turning their attention to the more common cells as their roles in the brain become better understood.
There are a variety of astrocyte cell types, and they perform such basic housekeeping tasks as helping to regulate blood flow, soaking up excess chemicals produced by interacting neurons, and controlling the blood-brain barrier, a protective filter that keeps dangerous molecules from entering the brain.
Astrocytes, some studies suggest, may even play a role in human intelligence, given that their volume is much greater in the human brain than any other species of animal.
Without the astrocyte, neurons can’t function. Astrocytes wrap around nerve cells to protect them and keep them healthy. They participate in virtually every function or disorder of the brain.
The ability to forge astrocytes in the lab has several potential practical outcomes, according to Zhang. They could be used as screens to identify new drugs for treating diseases of the brain, they can be used to model disease in the lab dish and, in the more distant future, it may be possible to transplant the cells to treat a variety of neurological conditions, including brain trauma, Parkinson’s disease, and spinal cord injury. It is possible that astrocytes prepared for clinical use could be among the first cells transplanted to intervene in a neurological condition, as the motor neurons affected by the fatal ALS (Lou Gehrig’s disease) are swathed in astrocytes.
With an injury or neurological condition, neurons in the brain have to work harder, and doing so they make more neurotransmitters.
Neurotransmitters are chemicals that – in excess – can be toxic to other cells in the brain.
One idea is that it may be possible to rescue motor neurons by putting normal, healthy astrocytes in the brain. These cells are really useful as a therapeutic target.
The technology developed by the Wisconsin group lays a foundation for making all the different types of astrocytes. What’s more, it is possible to genetically engineer them to mimic disease so that previously inaccessible neurological conditions can be studied in the lab.
Bottom line: A team led by University of Wisconsin-Madison stem cell researchers has been able to grow astrocytes in a lab dish. The results of their study appeared in the May 22, 2011 issue of the journal Nature Biotechnology. The ability to grow astrocytes from embryonic and induced human stem cells will enable lab studies of neurological conditions and new drugs.
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